Maddrey Score Calculator

The Maddrey Score Calculator is a clinical tool used to assess the severity of alcoholic hepatitis and to guide treatment decisions, particularly the need for corticosteroid therapy.

Historical Background

The Maddrey score, also known as the Maddrey Discriminant Function (MDF), was developed in the 1970s to predict outcomes in patients with alcoholic hepatitis. A high score suggests a poor prognosis and the potential need for corticosteroid treatment to reduce liver inflammation.

Calculation Formula

The Maddrey score is calculated using the following formula:

\[ \text{Maddrey Score} = 4.6 \times (\text{Prothrombin Time Difference}) + \text{Serum Bilirubin (mg/dL)} \]

Where:

• Prothrombin Time Difference is the difference in prothrombin time (PT) between the patient and normal control (in seconds).
• Serum Bilirubin is the concentration of bilirubin in the blood, measured in milligrams per deciliter (mg/dL).

Example Calculation

If a patient has a prothrombin time difference of 8 seconds and a serum bilirubin level of 10 mg/dL, the Maddrey score is calculated as:

\[ \text{Maddrey Score} = 4.6 \times 8 + 10 = 36.8 + 10 = 46.8 \]

Importance and Usage Scenarios

The Maddrey score helps clinicians assess the severity of alcoholic hepatitis. A score above 32 indicates severe disease, where the patient may benefit from corticosteroid therapy to reduce the risk of liver failure and death. Scores below 32 suggest a less severe condition, where corticosteroid treatment may not be necessary.

Common FAQs

1. What is the Maddrey score used for?

   • The Maddrey score is used to evaluate the severity of alcoholic hepatitis and predict mortality risk. It helps guide decisions on whether corticosteroid treatment is needed.

2. What does a Maddrey score above 32 mean?

   • A Maddrey score above 32 indicates severe alcoholic hepatitis, which may require corticosteroids to improve survival rates.

3. Can the Maddrey score be used for non-alcoholic liver diseases?

   • No, the Maddrey score is specifically designed for patients with alcoholic hepatitis. Other scoring systems are used for different types of liver disease.

4. What is prothrombin time (PT)?

   • Prothrombin time is a measure of how long it takes blood to clot. In liver disease, prolonged PT indicates impaired liver function.

The Maddrey Score Calculator is a valuable tool for assessing disease severity in patients with alcoholic hepatitis, helping clinicians make informed treatment decisions.